Functional Neural Transplantation
نویسندگان
چکیده
منابع مشابه
Neural Stem Cell Transplantation and Mechanisms for Functional Recovery
Neural stem cell transplantation has demonstrated its therapeutic potential in many neurological disorders. The long-thought prime mechanism of action was the replacement of cells lost to injury or neuro degeneration. Now, more and more evidence has provided insight into other bystander mechanisms through which these cell grafts could bring about a functional and structural restorative benefit....
متن کاملNeural Transplantation as a Strategy for Recovery of CNS Functions
Transplants of neural tissue have been used for nearly 100 years in order to clarify the mechanisms that underlie development and regeneration of the nervous system. With reports from Sweden and Mexico that autografts of adrenal medulla produce at least transient and perhaps dramatic improvement in patients severly disabled by Parkinson's disease, the techniques of neural transplantation have ...
متن کاملHuman neural retinal transplantation.
PURPOSE A pilot study of human neural retinal transplantation was undertaken to investigate three major issues: whether a safe surgical procedure could be devised for transplantation of neural retinal tissue into the subretinal space, whether the transplant would be accepted in the subretinal space, and whether an improvement in vision could be achieved. METHODS Eight patients with bare light...
متن کاملNeural transplantation in Parkinson's disease.
Parkinson's disease is a neurodegenerative disorder that affects about 1% of Canadians between the ages of fifty and seventy. The medical management for these patients consists of drug therapy that is initially effective but has limited long term benefits and does not alter the progressive course of the disease. The recalcitrance of longstanding Parkinson's disease to medical management has pro...
متن کاملHuman Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice
Huntington's disease (HD) is an inherited neurodegenerative disorder with no disease-modifying treatment. Expansion of the glutamine-encoding repeat in the Huntingtin (HTT) gene causes broad effects that are a challenge for single treatment strategies. Strategies based on human stem cells offer a promising option. We evaluated efficacy of transplanting a good manufacturing practice (GMP)-grade ...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 1995
ISSN: 1468-6244
DOI: 10.1136/jmg.32.4.327-a